Dichloromethane → 1H-Indazole-5-carbonitrile

HRID 398355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 398355
[C:1]([C:3]1[CH:4]=[CH:5][C:6](F)=[C:7]([CH:10]=1)[CH:8]=O)#[N:2].C(Cl)Cl.O.[NH2:16][NH2:17]>>[C:1]([C:3]1[CH:10]=[C:7]2[C:6](=[CH:5][CH:4]=1)[NH:17][N:16]=[CH:8]2)#[N:2]

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 24654Hydrazine hydrate (1:1)HCID 109097255-Cyano-2-fluorobenzaldehyde

Produkt 1

HCID 111263841H-Indazole-5-carbonitrile

Versuchsvorschrift

5-Cyano-2-fluorobenzaldehyde (512 mg, 3.43 mmol) was dissolved in hydrazine hydrate (25 mL) at room temperature and the solution left to stand overnight. To this reaction mixture was added methylene chloride (30 mL). The mixture was purified by filtration through a pad of silica eluting with methylene chloride, concentrated in vacuo to afford a white solid:

Aufarbeitung

  1. waitthe solution left
  2. filtrationThe mixture was purified by filtration through a pad of silica eluting with methylene chloride
  3. concentrationconcentrated in vacuo
  4. customto afford a white solid

Quellen und Nachweise

ORD-Eintrag
ord-af8254012b4749e383f127b9a2eb1307
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610692B1

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