Triethylamine → HCID 23000170, Verbindung

HRID 398366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 398366
[CH:1]1([CH2:4][CH2:5][CH2:6][CH2:7][OH:8])[CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C(Cl)Cl>[CH3:16][S:17]([O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:1]1[CH2:3][CH2:2]1)(=[O:19])=[O:18]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 230002214-Cyclopropylbutan-1-ol

Produkt 1

HCID 23000170HCID 23000170, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a stirred 0° C. solution of 683 mg (6.0 mmol) of 4-cyclopropylbutanol and 1.25 mL (9.0 mmol) of triethylamine in 10 mL of CH2Cl2 was added 697 μL (9.0 mmol) of methanesulfonyl chloride dropwise under Ar. The cold bath was allowed to expire over a 2 h period at which time the reaction mixture was diluted with CH2Cl2, washed with cold 1M HCl, water, sat. NaHCO3, brine, dried over MgSO4 and the solvents removed to give the title compound as a yellow oil:

Aufarbeitung

  1. washwashed with cold 1M HCl, water, sat. NaHCO3, brine
  2. dry with materialdried over MgSO4
  3. customthe solvents removed

Quellen und Nachweise

ORD-Eintrag
ord-ffeb22255aad496b8c70f40a043f0a49
Quelldatensatz
uspto-grants-2003_08
Patentnummer
US06610692B1

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