trans-3-Cyclopropylmethoxy-4-azidotetrahydrofuran → trans-3-Cyclopropylmethoxy-4-aminotetrahydrofuran
Reaktionsgleichung
[CH:1]1([CH2:4][O:5][C@H:6]2[C@H:10]([N:11]=[N+]=[N-])[CH2:9][O:8][CH2:7]2)[CH2:3][CH2:2]1>CCOC(C)=O.[Pd]>[CH:1]1([CH2:4][O:5][C@H:6]2[C@H:10]([NH2:11])[CH2:9][O:8][CH2:7]2)[CH2:2][CH2:3]1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of trans-3-cyclopropylmethoxy-4-azidotetrahydrofuran from step 3 above (1.2 g, mmol, 6.55 mmol) and 10% Pd on carbon (150 mg) in EtOAc (35 mL) was stirred under an atmosphere of hydrogen at ambient pressure and ambient temperature for 6 h. The catalyst was removed by filtration and the filtrate solvents were removed in vacuo to give the title compound as an oil (1.1 g, TLC Rf=0.3, 95:5:0.25 CH2Cl2:MeOH:NH4OH).
Aufarbeitung
- customThe catalyst was removed by filtration
- customthe filtrate solvents were removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-85099aea01ea450ea620184891a84ca8
- Quelldatensatz
- uspto-grants-2003_08
- Patentnummer
- US06610692B1
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