Potassium → (+/-)-3-Butyl-3-ethyl-2,3-dihydro-1,4-benzothiazepine

HRID 398821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 398821
[CH2:1]([C:5]1([CH2:16][CH3:17])[NH:11][CH2:10][C:9]2[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=2[S:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[K]>C(O)(C)(C)C.O>[CH2:1]([C:5]1([CH2:16][CH3:17])[N:11]=[CH:10][C:9]2[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=2[S:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 2

HCID 5462222PotassiumHCID 18968854(+/-)-3-Butyl-3-ethyl-2,3,4,5-tetrahydro-1,4-benzothiazepine

Produkt 1

HCID 18968787(+/-)-3-Butyl-3-ethyl-2,3-dihydro-1,4-benzothiazepineAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

To a solution of the product from step (b) (6.0 g) in tert-butyl alcohol (180 ml) was added a solution of potassium permangante (5.7 g) in water (90 ml). The mixture was heated to reflux for 10 minutes, cooled to room temperature, and filtered through celite. Solvent was evaporated to provide the title compound (5.9 g) as a colorless oil. 1H NMR consistent with the proposed structure.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 10 minutes
  3. filtrationfiltered through celite
  4. customSolvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-b138a27a123e467da2a8f5b77082f856
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05817652

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