Hydrochloric Acid → 4-[N'-(2-ethoxycarbonyl-1-acetyl ethylidene)hydrazino]benzene sulfonamide

HRID 399417

Reaktionsgleichung

Reaktionsgleichung von HRID 399417
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.Cl.[N:13]([O-])=O.[Na+].[CH2:17]([O:19][C:20](=[O:29])[CH2:21][CH:22](C(=O)C)[C:23](=[O:25])[CH3:24])[CH3:18]>C(O)C.O.C(O)C.N1C=CC=CC=1.O>[CH2:17]([O:19][C:20]([CH2:21][C:22](=[N:13][NH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:9])=[O:10])=[CH:4][CH:3]=1)[C:23](=[O:25])[CH3:24])=[O:29])[CH3:18]

Komponenten

9

Edukt 4

HCID 313Hydrochloric AcidHCID 5333SulfanilamideHCID 87820Ethyl 3-acetyl-4-oxopentanoateHCID 23668193Sodium Nitrite

Produkt 1

HCID 882324324-[N'-(2-ethoxycarbonyl-1-acetyl ethylidene)hydrazino]benzene sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittelHCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

To a suspension of 10 g. (58.1 mmoles) of 4-aminobenzenesulfonamide in 50 ml of 1:1 ethanol/water was added 7.3 ml. of concentrated hydrochloric acid. To the cooled mixture was added in portions 4.41 g (63.9 mmoles) of sodium nitrite in 5 ml. of water. The mixture was allowed to come to room temperature and after 15 minutes was poured into a solution of 11.9 g. (63.9 mmoles) of ethyl-3-acetyl-4-oxopentanoate in 12.2 ml. of pyridine and 25 ml. of ethanol. An orange solid began to separate which was collected after 30 minutes by filtration. After drying, 24.3 g. of material was obtained.

Aufarbeitung

  1. additionTo a suspension of 10 g
  2. additionwas poured into a solution of 11.9 g
  3. customto separate which
  4. filtrationwas collected after 30 minutes by filtration
  5. customAfter drying
  6. customof material was obtained

Quellen und Nachweise

ORD-Eintrag
ord-d87b2ffaa9194bad9f0689cf593347a0
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821243

Verknüpfte Notizen

Wird geladen…