(+-)-Pantolactone → Keto-pantoyllactone

HRID 399618

Reaktionsgleichung

Reaktionsgleichung von HRID 399618
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1.C([O-])(=O)C.[Na+].ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O>C(Cl)Cl>[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1

Komponenten

5

Edukt 3

HCID 989(+-)-PantolactoneHCID 6909Trichloroisocyanuric AcidHCID 517045Sodium Acetate

Produkt 1

HCID 39Keto-pantoyllactoneAusbeute 18,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

1.18 g (9.1 mmol) of pantolactone were dissolved in 27 ml of methylene chloride at 22° C. in a 50 ml reaction flask. 777 mg (9.5 mmol) of sodium acetate and 850 mg (3.7 mmol) of trichloroisocyanuric acid were added thereto. The mixture was cooled to 0° C. while stirring. 18.5% of ketopantolactone were obtained after a reaction period of 6 hours at 0° C. After a further reaction period of 20 hours at 22° C. the composition was 22.2% of ketopantolactone and 77.5% of pantolactone (area percent).

Quellen und Nachweise

ORD-Eintrag
ord-15decceb587c43bb898dbf689b247900
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05821374

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