Jineol → 3,8-Dimethoxy quinoline

HRID 399742

Reaktionsgleichung

Reaktionsgleichung von HRID 399742
[CH:1]1[CH:10]=[C:9]([OH:11])[C:8]2[N:7]=CC(O)=[CH:4][C:3]=2[CH:2]=1.[N+](=[CH2:15])=[N-].C[CH2:17][O:18][CH2:19][CH3:20]>C(O)C>[CH3:17][O:18][C:19]1[CH:20]=[N:7][C:8]2[C:3]([CH:4]=1)=[CH:2][CH:1]=[CH:10][C:9]=2[O:11][CH3:15]

Komponenten

4

Edukt 2

HCID 177338JineolHCID 21186548Diazomethane diethylether

Produkt 1

HCID 105837983,8-Dimethoxy quinolineAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Jineol of 4.5 mg was dissolved in 2 ml of ethanol, and diazomethane ether solution was slowly dropped to the solution. After the excess of diazomethane and solvent was removed by purging with nitrogen gas, the solution was purified by silicagel chromatography to give 4.2 mg of 3,8-dimethoxy quinoline with 80% yield.

Aufarbeitung

  1. customAfter the excess of diazomethane and solvent was removed
  2. customby purging with nitrogen gas
  3. customthe solution was purified by silicagel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-a3d35d944aca43608a8e9c356519b602
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05824689

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