4-Aminobutanal → HCID 18944389, Verbindung

HRID 400218

Reaktionsgleichung

Reaktionsgleichung von HRID 400218
[NH2:1][CH2:2][CH2:3][CH2:4][CH:5]=[O:6].[CH2:7](Br)[CH2:8][CH2:9][CH3:10].[OH-].[Na+]>C(O)C>[CH2:7]([N:1]([CH2:2][CH2:3][CH2:4][CH3:5])[CH2:2][CH2:3][CH2:4][CH:5]=[O:6])[CH2:8][CH2:9][CH3:10]

Komponenten

5

Edukt 3

HCID 1184-AminobutanalHCID 8002Butyl bromideHCID 14798Sodium Hydroxide

Produkt 1

HCID 18944389HCID 18944389, VerbindungAusbeute 39 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A! A solution of 4-aminobutyraldehyde diethylacetale (90 ml, 0.5 mole) and butyl bromide (121 ml, 1.1 mole) in ethanol (1.000 ml) was added with a 1N solution of sodium hydroxide (1.130 ml). The reaction mixture was refluxed for 8 hours. The reaction solvent was evaporated off and the aqueous solution was extracted with diethyl ether. The organic phases were combined and anhydrified over sodium sulfate, then evaporated under vacuum. The resulting crude was purified by fractionated distillation to yield 54 g of 4-dibutylaminobutyraldehyde diethylacetale (yield: 39%). B.p.: 95°-06° C. (0,05 mmHg).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 8 hours
  2. customThe reaction solvent was evaporated off
  3. extractionthe aqueous solution was extracted with diethyl ether
  4. customevaporated under vacuum
  5. distillationThe resulting crude was purified by fractionated distillation

Quellen und Nachweise

ORD-Eintrag
ord-ff738e2080e34a5382cf0f8aad79fbd6
Quelldatensatz
uspto-grants-1998_10
Patentnummer
US05827881

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