Potassium Carbonate → 4-Hydroxy-3-methylbenzonitrile

HRID 400592Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 400592
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][C:6]=1[CH3:13])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][C:6]=1[CH3:13]

Komponenten

5

Edukt 2

HCID 11430Potassium CarbonateHCID 552203614-Cyano-2-methylphenyl acetate

Produkt 1

HCID 109645604-Hydroxy-3-methylbenzonitrileAusbeute 78,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A stirred solution of 4-cyano-2-methylphenyl acetate (5.2 g, 29.7 mmol) in 75 mL of methanol was treated with a solution of potassium carbonate (30 mmol, 4.15 g) in 25 mL of water at room temperature. After 30 minutes, the mixture was concentrated in vacuo and treated with 1 N sulfuric acid. The resulting precipitate was filtered, washed with water, and dried to give 3.1 g of 4-hydroxy-3-methylbenzonitrile as a white solid (78% yield).

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. additiontreated with 1 N sulfuric acid
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-87c6b5bbd2404f0b9177c6f110a986e3
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741897B2

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