4-Hydroxy-3-methylbenzonitrile → HCID 67141374, Verbindung

HRID 400593Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 400593
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH3:10].F[B-](F)(F)F.[O:16]=[N+:17]=[O:18]>C(#N)C.O>[OH:1][C:2]1[C:9]([N+:17]([O-:18])=[O:16])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH3:10]

Komponenten

5

Edukt 2

HCID 109645604-Hydroxy-3-methylbenzonitrileHCID 11073463Nitronium tetrafluoroborate

Produkt 1

HCID 67141374HCID 67141374, VerbindungAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

A stirred solution of 4-hydroxy-3-methylbenzonitrile (3.1 g, 23.3 mmol) in 60 mL of anhydrous acetonitrile was cooled to −30° C. and treated with nitronium tetrafluoroborate (3.4 g, 25.6 mmol) in portions. After 60 minutes, the reaction mixture was diluted with 100 mL of water. The resulting light yellow precipitate was filtered, washed with water, and dried to give 3.9 g of 4-hydroxy-3-methyl-5-nitrobenzonitrile (94% yield).

Aufarbeitung

  1. filtrationThe resulting light yellow precipitate was filtered
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9bd1239af7614a7b8aafa67a12e09874
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741897B2

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