2-Methoxy-3-nitropyridine → 3-Amino-2-methoxypyridine

HRID 401585

Reaktionsgleichung

Reaktionsgleichung von HRID 401585
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][CH:6]=[CH:5][N:4]=1>CO.[Pd]>[CH3:1][O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][N:4]=1

Komponenten

4

Edukt 1

HCID 2532192-Methoxy-3-nitropyridine

Produkt 1

HCID 27374883-Amino-2-methoxypyridineAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2-methoxy-3-nitro-pyridine (70. g, 0.45 mol) in methanol (700 mL) containing palladium on carbon (7 g, 10%) was stirred under an atmosphere of hydrogen for 15 hours. The catalyst was filtered and washed with methanol. The filtrate was evaporated to dryness to give crude 2-methoxy-pyridin-3-ylamine (48 g, 0.39 mol, 87%), which was used directly in the next step.

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. washwashed with methanol
  3. customThe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a4a258994c364f5d8376e8f8bf129688
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08741939B2

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