Potassium Carbonate → HCID 66765091, Verbindung

HRID 402756

Reaktionsgleichung

Reaktionsgleichung von HRID 402756
C(=O)([O-])[O-].[K+].[K+].Cl.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O=[C:17]([C:24]1[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=1[F:32])[CH2:18][C:19](OCC)=[O:20]>CCO>[C:8]1([N:14]2[C:19](=[O:20])[CH2:18][C:17]([C:24]3[CH:29]=[C:28]([F:30])[C:27]([F:31])=[CH:26][C:25]=3[F:32])=[N:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 60962Phenylhydrazine hydrochlorideHCID 2758933Ethyl 2,4,5-trifluorobenzoylacetate

Produkt 1

HCID 66765091HCID 66765091, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Potassium carbonate (153 mg, 1.10 mmol) was added to a stirred mixture of phenyl hydrazine HCl salt (160 mg, 1.10 mmol) and ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate (272 mg, 1.10 mmol) in EtOH (6 mL) and the mixture was heated at 70° C. for 1 hour. The solution was cooled to room temperature and was concentrated to give the title compound, which was taken on to the next step.

Aufarbeitung

  1. temperatureThe solution was cooled to room temperature
  2. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-3b8aeac09dcf44bfbc8b68645c6200f3
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08742110B2

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