Hydrochloric Acid → 4-Chloro-2-aminobutanoic acid hydrochloride

Temperatur

70 °C

Approximately 1 equivalent of homoserine, 0.01 equivalent of sulfuric acid may be combined with water in a reactor. The reactor may be sealed and 1.1 equivalent of anhydrous HCl (gas) may be may be added to the reactor. The reaction mixture may be heated to about 70° C. and maintained at about 80 psi for about 24 hours. The reaction mixture may be cooled and about 10 equivalents of methanol may be added, such that the product precipitates. The product (i.e., 4-chloro-2-aminobutanoic acid hydrochloride) may be isolated by filtration.

1. customThe reactor may be sealed
2. temperaturemaintained at about 80 psi for about 24 hours
3. temperatureThe reaction mixture may be cooled
4. customprecipitates

ORD-Eintrag

ord-4129312609fa4a3eadb5a7d6485cdc1a

Quelldatensatz

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08742170B2