Venlafaxine Hydrochloride → Venlafaxine

HRID 403103

Reaktionsgleichung

Reaktionsgleichung von HRID 403103
[CH3:1][N:2]([CH2:4][CH:5]([C:14]1([OH:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:6]1[CH:7]=[CH:8][C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:3].Cl>O>[CH3:1][N:2]([CH2:4][CH:5]([C:14]1([OH:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:6]1[CH:7]=[CH:8][C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:3]

Komponenten

3

Edukt 1

HCID 62923Venlafaxine Hydrochloride

Produkt 1

HCID 5656Venlafaxine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

The Venlafaxine Resin Complex was prepared by first dissolving 500 g of venlafaxine HCl in 5 L of purified water, and then slowly adding 1,000 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. EUDRAGIT™ NE-30D polymer of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was dried in a 50° C. VWR™ convection oven to the moisture content around 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

Aufarbeitung

  1. additionslowly adding 1,000 g of AMBERLITE™
  2. additionThe dispersion was mixed for 4 hours and upon completion
  3. custombefore decanting the supernatant
  4. customThe wet resin complex was then dried in a VWR™ convection oven
  5. additionEUDRAGIT™ NE-30D polymer of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
  6. customto form a uniform mass
  7. customThe wet mass was dried in a 50° C
  8. customThe dried granules were then milled through a 40 mesh screen

Quellen und Nachweise

ORD-Eintrag
ord-0baf853e083f403fb6cd3281da3db537
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08747902B2

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