Hydrogen Peroxide → HCID 178526288, Verbindung
Reaktionsgleichung
[OH:1]O.[N:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1>CC(O)=O>[N+:3]1([O-:1])[C:11]2[CH:10]=[CH:9][CH:8]=[N:7][C:6]=2[NH:5][CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
Hydrogen peroxide (30 wt % solution in water, 38.0 ml, 372 mmol) was added to a suspension of 3H-imidazo[4,5-b]pyridine (4.93 g, 41.4 mmol) in AcOH (40 mL) at room temperature. The resulting reaction mixture was stirred at 80° C. for 3 h, cooled to RT and concentrated in vacuo to a volume ˜50 mL. Concentration to dryness was done using a stream of N2. The resulting residue was suspended in water (˜10 mL). Filtration afforded the title compound (4.61 g, 82.4% yield).
Aufarbeitung
- customThe resulting reaction mixture
- temperaturecooled to RT
- concentrationconcentrated in vacuo to a volume ˜50 mL
- concentrationConcentration to dryness
- filtrationFiltration
Quellen und Nachweise
- ORD-Eintrag
- ord-e8585171280146ac9eb86621d1c56313
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08524900B2
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