Water → HCID 67307990, Verbindung

HRID 404127Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 404127
Br[CH2:2][C:3]1[CH:4]=[C:5]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[CH2:9]Br.C(=O)([O-])[O-].[K+].[K+].[CH3:26][O:27][C:28](=[O:34])[C@H:29]([CH:31]([CH3:33])[CH3:32])[NH2:30].O>C(#N)C>[CH3:32][CH:31]([CH3:33])[CH:29]([N:30]1[CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[C:5]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[CH:4]=2)[CH2:9]1)[C:28]([O:27][CH3:26])=[O:34]

Komponenten

6

Edukt 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 94285Valine methyl esterHCID 673071543,4-bis(Bromomethyl)-4'-nitrobiphenyl

Produkt 1

HCID 67307990HCID 67307990, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

The compound of example 671 (3 g, 7.79 mmol) was taken in acetonitrile and to the reaction mixture, potassium carbonate (3.25 g, 23.37 mmol) was added followed by the addition of valine methyl ester (1.56 g, 9.35 mmol). The reaction mixture was refluxed for about 16 h and water was added to quench the reaction. The aqueous mixture was extracted with ethyl acetate to obtain a crude material, which was purified using column chromatography (silicagel, 30% ethyl acetate in petroleum ether).

Aufarbeitung

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed for about 16 h
  3. customto quench
  4. customthe reaction
  5. extractionThe aqueous mixture was extracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-836010156a004d728a8f4cde327f0724
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08748426B2

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