Benzoic Acid → 5-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

HRID 40565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 40565
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:16]=[CH:15][C:14]([NH2:17])=[C:13](Cl)[N:12]=1>O=P(Cl)(Cl)Cl>[Cl:10][C:11]1[N:12]=[CH:13][C:14]2[N:17]=[C:1]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[O:9][C:15]=2[N:16]=1

Komponenten

4

Edukt 2

HCID 243Benzoic AcidHCID 2577975-Amino-2,4-dichloropyrimidine

Produkt 1

HCID 149130905-Chloro-2-phenyloxazolo[5,4-d]pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24813Phosphorus oxychlorideLösungsmittel

Versuchsvorschrift

7.82 g (64.0 mmol) benzoic acid and 20 mL POCl3 are stirred together at 100° C. for 30 min. Within 45 min 7.00 g (42.7 mmol) 2,6-dichloro-5-aminopyrimidine are added by several portions. The reaction mixture is stirred for additional 2 h at the same temperatur. After that the mixture is carefully added to an ice cold aq. NaOH solution. The resulting precipitate is filtered, washed with water and dried.

Aufarbeitung

  1. filtrationThe resulting precipitate is filtered
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0a7236edd7b34ad4bd3310e7c1c86518
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530460B2

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