Water → Ethyl 4-(2-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethylamino)-4-oxobutanoate

HRID 406220Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 406220
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]3[CH2:23][CH2:22][CH2:21][N:20]([CH2:24][CH2:25][NH2:26])[C:10]3=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:3][CH:2]=1.C(N([CH2:33][CH3:34])CC)C.C([CH:37]([CH2:41][C:42](Cl)=[O:43])[C:38](Cl)=[O:39])C.[OH2:45]>C(OCC)(=O)C>[C:1]1([CH3:27])[CH:2]=[CH:3][C:4]([C:7]2[N:8]=[C:9]3[CH2:23][CH2:22][CH2:21][N:20]([CH2:24][CH2:25][NH:26][C:42](=[O:43])[CH2:41][CH2:37][C:38]([O:39][CH2:33][CH3:34])=[O:45])[C:10]3=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)=[CH:5][CH:6]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 218646082-Ethylbutanedioyl dichlorideHCID 666659362-(2,3-Dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethanamine

Produkt 1

HCID 66666378Ethyl 4-(2-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethylamino)-4-oxobutanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture comprising 2-(2,3-dip-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)ethanamine (step 2) (108 mg, 0.301 mmol) in ethyl acetate (5 ml) and triethylamine (0.084 ml, 0.603 mmol) at RT was treated dropwise with ethyl succinyl chloride (74.4 mg, 0.452 mmol) and the resulting suspension was stirred at RT for 30 minutes. The mixture was poured into water and extracted with ethyl acetate. The organic layer was separated, dried over and concentrated in vacuo to afford the title compound;

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was separated
  3. customdried over and
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4182bbc5ebd74ede9648726c6fd7a795
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754085B2

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