Tetrabutylammonium Fluoride → (3-pyrrolidin-1-ylphenyl)methanol

HRID 406388Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 406388
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][CH2:27][C:28]1[CH:29]=[C:30]([N:34]2[CH2:38][CH2:37][CH2:36][CH2:35]2)[CH:31]=[CH:32][CH:33]=1)(C(C)(C)C)(C)C>C1COCC1>[N:34]1([C:30]2[CH:29]=[C:28]([CH2:27][OH:26])[CH:33]=[CH:32][CH:31]=2)[CH2:38][CH2:37][CH2:36][CH2:35]1

Komponenten

4

Edukt 2

HCID 2724141Tetrabutylammonium FluorideHCID 66618917HCID 66618917, Verbindung

Produkt 1

HCID 7162062(3-pyrrolidin-1-ylphenyl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Tetrabutylammonium fluoride (1.0 M solution in THF, 3.8 ml) was added to a solution of 1-[3-(tert-butyldimethylsilyloxymethyl)phenyl]pyrrolidine in THF (20 ml) and the mixture was stirred at room temperature for 3.5 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound (557 mg).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-64db9458e0cf4711a293e8a8f1c1930e
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754100B2

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