Methylamine → Methyl 3-(methylamino)but-2-enoate

HRID 406576

Reaktionsgleichung

Reaktionsgleichung von HRID 406576
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH3:9][NH2:10]>O>[CH3:9][NH:10][C:3]([CH3:5])=[CH:2][C:1]([O:7][CH3:8])=[O:6]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 7757Methyl acetoacetate

Produkt 1

HCID 2734182Methyl 3-(methylamino)but-2-enoateAusbeute 80,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of methyl acetoacetate (23.2 g, 0.2 mol) in water (15 mL) at 10° C. was added dropwise methylamine (40% aqueous solution, 18.6 g, 0.24 mol). The reaction mixture was allowed to warm to room temperature and stirred for 2 h. The resulting solid precipitate was collected by filtration and washed with ice water (2×), and then dried in a vacuum oven at 55° C. overnight to provide the title compound as a white solid (20.9 g).

Aufarbeitung

  1. filtrationThe resulting solid precipitate was collected by filtration
  2. washwashed with ice water (2×)
  3. customdried in a vacuum oven at 55° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-3ba519176bf343d28ba6aba20ef70601
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754115B2

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