Hydrochloric Acid → Hydrochloric Acid

HRID 406992Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 406992
C(OC([N:6]1[CH:10]=[C:9]([C:11]2[CH:34]=[CH:33][C:14]3[N:15]([C:18]4[CH:19]=[C:20]([NH:24][C:25]([NH:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:26])[CH:21]=[CH:22][CH:23]=4)[CH:16]=[N:17][C:13]=3[CH:12]=2)[CH:8]=[N:7]1)C)C.[ClH:35].O>O1CCCC1>[NH:6]1[CH:10]=[C:9]([C:11]2[CH:34]=[CH:33][C:14]3[N:15]([C:18]4[CH:19]=[C:20]([NH:24][C:25]([NH:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[O:26])[CH:21]=[CH:22][CH:23]=4)[CH:16]=[N:17][C:13]=3[CH:12]=2)[CH:8]=[N:7]1.[ClH:35]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 67980487N-(3-{5-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-1-yl]phenyl)-N'-(2,2,2-trifluoroethyl)urea

Produkt 2

HCID 313Hydrochloric AcidHCID 67980057N-{3-[5-(1H-pyrazol-4-yl)-1H-benzimidazol-1-yl]phenyl}-N'-(2,2,2-trifluoroethyl)urea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The mixture of N-(3-{5-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-1H-benzimidazol-1-yl}phenyl)-N′-(2,2,2-trifluoroethyl)urea (190 mg, 0.40 mmol) and 1.0 M hydrogen chloride in water (3 mL, 3 mmol) in tetrahydrofuran (5 mL) was stirred at r.t. 2 hours. The reaction mixture was concentrated under reduced pressure to dryness to afford the desired compound as HCl salt which was directly used in next step reaction without further purification. LCMS (M+H)+: m/z=401.2.

Aufarbeitung

  1. custom2 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure to dryness

Quellen und Nachweise

ORD-Eintrag
ord-661cda71e74b4fae9c3a179727984545
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754114B2

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