(S)-(+)-Tetrahydrofurfurylamine → US10213427, Example 100

HRID 407088

Reaktionsgleichung

Reaktionsgleichung von HRID 407088
[F:1][C:2]([F:35])([F:34])[CH2:3][NH:4][C:5]([NH:7][C:8]1[CH:9]=[C:10]([C:14]2[N:18]3[N:19]=[CH:20][C:21]([C:23]4[CH:28]=[CH:27][C:26]([CH:29]([CH3:33])[C:30](O)=[O:31])=[CH:25][CH:24]=4)=[CH:22][C:17]3=[N:16][CH:15]=2)[CH:11]=[CH:12][CH:13]=1)=[O:6].[O:36]1[CH2:40][CH2:39][CH2:38][C@H:37]1[CH2:41][NH2:42]>>[O:36]1[CH2:40][CH2:39][CH2:38][C@H:37]1[CH2:41][NH:42][C:30](=[O:31])[CH:29]([C:26]1[CH:25]=[CH:24][C:23]([C:21]2[CH:20]=[N:19][N:18]3[C:14]([C:10]4[CH:11]=[CH:12][CH:13]=[C:8]([NH:7][C:5]([NH:4][CH2:3][C:2]([F:35])([F:34])[F:1])=[O:6])[CH:9]=4)=[CH:15][N:16]=[C:17]3[CH:22]=2)=[CH:28][CH:27]=1)[CH3:33]

Komponenten

3

Edukt 2

HCID 641530(S)-(+)-TetrahydrofurfurylamineHCID 679801572-(4-{3-[3-({[(2,2,2-Trifluoroethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}phenyl)propanoic acid

Produkt 1

HCID 57386930US10213427, Example 100

Versuchsvorschrift

This compound was prepared by using procedure analogous to those described for the synthesis of Example 98, Step 9 starting from 2-(4-{3-[3-({[(2,2,2-trifluoroethyl)amino]carbonyl}amino)phenyl]imidazo[1,2-b]pyridazin-7-yl}phenyl)propanoic acid and 1-[(25)-tetrahydrofuran-2-yl]methanamine. LCMS (M+H)+: m/z=567.3

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-0a413573f2d449a0b0b513fbe09f877a
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754114B2

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