Hydrazine hydrate (1:1) → HCID 178434638, Verbindung

HRID 407297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 407297
[Br:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]=[C:7]([C:9](=[C:12](OC)[CH3:13])[C:10]#[N:11])[S:8][C:4]=2[CH:3]=1.O.[NH2:19][NH2:20]>CO>[Br:1][C:2]1[CH:17]=[CH:16][C:5]2[N:6]=[C:7]([C:9]3[C:12]([CH3:13])=[N:20][NH:19][C:10]=3[NH2:11])[S:8][C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 667681932-(6-Bromobenzothiazol-2-yl)-3-methoxybut-2-enenitrile

Produkt 1

HCID 178434638HCID 178434638, VerbindungAusbeute 5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2-(6-bromobenzothiazol-2-yl)-3-methoxybut-2-enenitrile (0.96 g, 3.1 mmol) and hydrazine hydrate (0.3 mL, 5.4 mmol) in methanol (30 mL) was heated to reflux overnight. The reaction was then cooled to room temperature. The resulting solid was isolated by filtration and was purified by flash chromatography to yield the title product. MS (m/z, ES+): 308.9 (Br79M+1, 100%), 310.9 (Br81 M+1, 100%). Yield=5%.

Aufarbeitung

  1. temperatureto reflux overnight
  2. customThe resulting solid was isolated by filtration
  3. customwas purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4e2fc4d333084e0a8d5c1084ab90a73f
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08754233B2

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