Ammonia → 2-Phthalimidoethanesulfonamide

HRID 40757

Reaktionsgleichung

Reaktionsgleichung von HRID 40757
[C:1]1(=[O:17])[N:5]([CH2:6][CH2:7][S:8](Cl)(=[O:10])=[O:9])[C:4](=[O:12])[C:3]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:2]12.[NH3:18]>O1CCOCC1.O>[C:1]1(=[O:17])[N:5]([CH2:6][CH2:7][S:8]([NH2:18])(=[O:10])=[O:9])[C:4](=[O:12])[C:3]2=[CH:13][CH:14]=[CH:15][CH:16]=[C:2]12

Komponenten

5

Edukt 2

HCID 222AmmoniaHCID 3087392-Phthalimidoethanesulfonyl chloride

Produkt 1

HCID 960922-Phthalimidoethanesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

2-Phthalimidoethanesulfonyl chloride (2.0 g) was added portion wise to a solution of 0.5 M of ammonia in dioxane (15 ml) and the solution obtained this way was stirred at room temperature. After 48 hours the reaction mixture was poured in water (50 ml) causing the title compound to precipitate. The product was collected by filtration. Yield: 1.52 g (83%) of a solid. 1H-NMR (DMSO-δ6) δ (ppm) 7.92-713 (m, 4H), 7.06 (s, 2H), 6.88-3.93 (m, 2H), 3.37-3.30 (m, 2H).

Aufarbeitung

  1. customthe solution obtained this way

Quellen und Nachweise

ORD-Eintrag
ord-01d3b421636a46c9afeff37871c6b667
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530486B2

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