2-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenyl → (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(1-(5-methoxypyrazin-2-yl)piperidin-4-yl)pyrrolidin-2-one

Reaktionsgleichung

[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:12][C@H:13]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:14]1=[O:24].Br[C:26]1[CH:31]=[N:30][C:29]([O:32][CH3:33])=[CH:28][N:27]=1.CC([O-])(C)C.[Na+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C=CC=CC=2N(C)C)CCCCC1>CC([O-])=O.CC([O-])=O.[Pd+2].C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[NH:12][C@H:13]1[CH2:17][CH2:16][N:15]([CH:18]2[CH2:23][CH2:22][N:21]([C:26]3[CH:31]=[N:30][C:29]([O:32][CH3:33])=[CH:28][N:27]=3)[CH2:20][CH2:19]2)[C:14]1=[O:24]