Benzo[d]thiazol-5-ylmethanol → 1,3-Benzothiazole-5-carbaldehyde

HRID 408575Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 408575
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][OH:11])=[CH:9][C:4]=2[N:3]=[CH:2]1>C(Cl)Cl.O=[Mn]=O>[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

Komponenten

4

Edukt 1

HCID 22281733Benzo[d]thiazol-5-ylmethanol

Produkt 1

HCID 218737181,3-Benzothiazole-5-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

To a solution of benzothiazol-5-yl-methanol (1 eq.) in DCM was added MnO2 (10 eq.). The dark suspension was stirred at 20° C. for 15 h, filtered through a pad of celite and the solvent removed under reduced pressure to afford benzothiazole-5-carbaldehyde which was used as such without further purification.

Aufarbeitung

  1. filtrationfiltered through a pad of celite
  2. customthe solvent removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-369831751b674dc4b9a51dbd8cf70f4a
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759334B2

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