Water → 5,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-One

HRID 408674

Reaktionsgleichung

Reaktionsgleichung von HRID 408674
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:10])[C:5]([NH2:9])=[CH:6][C:7]=1[Cl:8].O.CN([CH:15]=[O:16])C>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]2[NH:9][C:15](=[O:16])[NH:10][C:4]=2[CH:3]=1

Komponenten

4

Edukt 3

HCID 962WaterHCID 6228DimethylformamideHCID 792974,5-Dichloro-1,2-phenylenediamine

Produkt 1

HCID 98991485,6-Dichloro-1,3-Dihydro-2H-Benzimidazol-2-OneAusbeute 90 %

Versuchsvorschrift

To the solution of 4,5-dichloro-benzene-1,2-diamine (25 g, 0.14 mol) in dry DMF (200 mL), was added CU (23 g, 0.14 mol) as the solid. The reaction solution was stirred at room temperature for 1 hour, then water (500 mL) was added. The precipitated solid was collected by filtration, washed with water, dried thoroughly to afford the titled compound (26.0 g, 90%). The crude product was used in the following reaction without further purification.

Aufarbeitung

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried thoroughly

Quellen und Nachweise

ORD-Eintrag
ord-32e380d95b384ff68651510f7cc8c2b2
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759345B2

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