Dimethylformamide → 4-(2',6'-Dimethylphenoxy)phthalonitrile

HRID 409217

Reaktionsgleichung

Reaktionsgleichung von HRID 409217
[N+]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9])([O-])=O.[CH3:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=1[OH:22].C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[CH3:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=1[O:22][C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7](=[CH:10][CH:11]=1)[C:8]#[N:9]

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 113352,6-DimethylphenolHCID 11430Potassium CarbonateHCID 974431,2-Benzenedicarbonitrile, 4-nitro-

Produkt 1

HCID 9520734-(2',6'-Dimethylphenoxy)phthalonitrileAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 4-nitro-phthalonitrile (1 eq), 2,6-dimethylphenol (1.2 eq), K2CO3 (2 eq), and DMF (1 mL/mmol 4-nitro-phthalonitrile) was heated under nitrogen at 60° C. for 3 h with stirring. After cooling to ambient temperature the mixture was poured into water (6 mL/mL DMF) with stirring. The mixture was extracted twice with EtOAc. The combined organic phases were dried over MgSO4 and concentrated in vacuo. The residue was recrystallized from EtOH to give the title compound as a tan solid (yield: 87%); 1H NMR (CDCl3, 200 MHz): δ=7.70 (d, 1H), 7.05 to 7.16 (m, 5H), 2.08 (s, 6H).

Aufarbeitung

  1. temperatureAfter cooling to ambient temperature the mixture
  2. stirringwith stirring
  3. extractionThe mixture was extracted twice with EtOAc
  4. dry with materialThe combined organic phases were dried over MgSO4
  5. concentrationconcentrated in vacuo
  6. customThe residue was recrystallized from EtOH

Quellen und Nachweise

ORD-Eintrag
ord-9978a0cb1dd743ffa8a7648d2010ff6b
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759373B2

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