Sodium Hydroxide → 3-Nitro-2,4-dimethyl-benzylamine

HRID 410080

Reaktionsgleichung

Reaktionsgleichung von HRID 410080
[N+:1]([C:4]1[C:5]([CH3:19])=[C:6]([CH:15]=[CH:16][C:17]=1[CH3:18])[CH2:7][NH:8]C(=O)C(F)(F)F)([O-:3])=[O:2].[OH-].[Na+]>CO>[N+:1]([C:4]1[C:5]([CH3:19])=[C:6]([CH:15]=[CH:16][C:17]=1[CH3:18])[CH2:7][NH2:8])([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 56840191N-(3-Nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide

Produkt 1

HCID 568399723-Nitro-2,4-dimethyl-benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of N-(3-nitro-2,4-dimethyl-benzyl)-2,2,2-trifluoroacetamide (1.53 g, 5.54 mmol), 4M NaOH-solution (6.9 mL, 28 mmol) and MeOH (30 mL) is refluxed for 2 h. Then the mixture is concentrated, diluted with water and extracted with EtOAc. The organic phase is dried with Na2SO4, filtered and concentrated.

Aufarbeitung

  1. temperatureis refluxed for 2 h
  2. concentrationThen the mixture is concentrated
  3. additiondiluted with water
  4. extractionextracted with EtOAc
  5. dry with materialThe organic phase is dried with Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-c4c97e65efa749e0aa4adeb21e27d809
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759537B2

Verknüpfte Notizen

Wird geladen…