6-Fluoroindole → Sodium 6-Fluoro-1H-indole-2-sulfonate

HRID 41066

Reaktionsgleichung

Reaktionsgleichung von HRID 41066
[S:1](=[O:4])([OH:3])[O-:2].[Na+:5].[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[CH:12][NH:13]2)=[CH:9][CH:8]=1>O.C(O)C>[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[C:12]([S:1]([O-:3])(=[O:2])=[O:4])[NH:13]2)=[CH:9][CH:8]=1.[Na+:5]

Komponenten

5

Edukt 2

HCID 3512786-FluoroindoleHCID 23665763Sodium Bisulfite

Produkt 1

HCID 86634332Sodium 6-Fluoro-1H-indole-2-sulfonateAusbeute 29,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 23.4 g sodium bisulfite in 80 ml water a solution of 13.5 g 6-fluoro indole in ethanol is added drop wise. The obtained suspension is stirred at room temperature over night. The precipitate is filtered and washed with cold water, cold methanol and diethyl ether. 7.0 g (29%) of the title compound are obtained as a colourless solid.

Aufarbeitung

  1. filtrationThe precipitate is filtered
  2. washwashed with cold water, cold methanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-524347121123467c90bcf38b3fc5d8c2
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530493B2

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