HCID 59395139, Verbindung → HCID 67333436, Verbindung

HRID 410766Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 410766
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[F:15]>[Pd]>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[F:15]

Komponenten

3

Edukt 1

HCID 59395139HCID 59395139, Verbindung

Produkt 1

HCID 67333436HCID 67333436, VerbindungAusbeute 88,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 23938PalladiumKatalysator

Versuchsvorschrift

5-Amino-2-fluoro-4-methylamino-benzoic acid methyl ester (115 mg) was prepared by following General Procedure B starting from 2-fluoro-4-methylamino-5-nitro-benzoic acid methyl ester (150 mg) and Pd/C (10% by weight, 15 mg). The crude product was used in the next step without further purification.

Aufarbeitung

  1. customThe crude product was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-bb4a58489da942f2b8b4ab9e3527896c
Quelldatensatz
uspto-grants-2014_06
Patentnummer
US08759535B2

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