6-Methylamino-5-nitro-nicotinic acid ethyl ester → 5-Amino-6-methylamino-nicotinic acid ethyl ester
Reaktionsgleichung
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH:14][CH3:15])=[N:7][CH:6]=1)[CH3:2]>[Pd]>[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH:14][CH3:15])=[N:7][CH:6]=1)[CH3:2]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
5-Amino-6-methylamino-nicotinic acid ethyl ester (723 mg) was prepared by following General Procedure B starting from 6-methylamino-5-nitro-nicotinic acid ethyl ester (911 mg) and Pd/C (10% by weight, 90 mg). The crude product was used in the next step without further purification.
Aufarbeitung
- customThe crude product was used in the next step without further purification
Quellen und Nachweise
- ORD-Eintrag
- ord-a4c38adfc2dc4e5ba655597fa0fdc514
- Quelldatensatz
- uspto-grants-2014_06
- Patentnummer
- US08759535B2
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