HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-(2-Chloroethyl)dibenzylamine → N,N-Dibenzyl-N'-(2-fluoro-ethyl)ethane-1,2-diamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-(2-Chloroethyl)dibenzylamine | HCID 5820 | — |
| Edukt | Ethanamine, 2-fluoro-, hydrochloride | HCID 9995 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Katalysator | Tetrabutylammonium Bromide | HCID 74236 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N,N-Dibenzyl-N'-(2-fluoro-ethyl)ethane-1,2-diamine | HCID 86656909 | 27,9% |
Reaktionsschritte
N,N-Dibenzyl-N′-(2-fluoro-ethyl)ethane-1,2-diamine (160 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (520 mg), 2-fluoro-ethylamine hydrochloride (250 mg), DIEA (900 uL) and tetrabutylammonium bromide (60 mg) in DMF (2 mL).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08759535B2 |
| Quelldatensatz | uspto-grants-2014_06 |
| ORD ID | ord-5a18b1a3eb32402cb0d51adcaa7437dd |
| Quellennotiz | uspto-grants-2014_06 |