N-(2-Chloroethyl)dibenzylamine → N,N-Dibenzyl-N'-(2-fluoro-ethyl)ethane-1,2-diamine

HRID 410996노트

반응식

HRID 410996 반응식
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[F:20][CH2:21][CH2:22][NH2:23].CCN(C(C)C)C(C)C>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.CN(C=O)C>[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10][NH:23][CH2:22][CH2:21][F:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 5820N-(2-Chloroethyl)dibenzylamineHCID 9995Ethanamine, 2-fluoro-, hydrochlorideHCID 81531Diisopropylethylamine

생성물 1

HCID 86656909N,N-Dibenzyl-N'-(2-fluoro-ethyl)ethane-1,2-diamine수율 27.9%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 6228Dimethylformamide용매

실험 절차

N,N-Dibenzyl-N′-(2-fluoro-ethyl)ethane-1,2-diamine (160 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (520 mg), 2-fluoro-ethylamine hydrochloride (250 mg), DIEA (900 uL) and tetrabutylammonium bromide (60 mg) in DMF (2 mL).

출처 및 근거

ORD 기록
ord-5a18b1a3eb32402cb0d51adcaa7437dd
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

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