1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 411156

Reaktionsgleichung

Reaktionsgleichung von HRID 411156
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

Produkt 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazineAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

Aufarbeitung

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

Quellen und Nachweise

ORD-Eintrag
ord-0b8309128be54490ac5ad24413da23b1
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559143B1

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