Sodium Iodide → 2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

HRID 4113Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 4113
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)=[O:4].[I-:28].[Na+]>CC(C)=O>[I:28][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:8]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:7]=1)=[O:4]

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 201534662-Chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

Produkt 1

HCID 201534732-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamideAusbeute 60,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

Aufarbeitung

  1. filtrationThe reaction was filtered hot
  2. customto remove the sodium iodide
  3. customa precipitate formed in the cold filtrate which
  4. customwas collected
  5. washwashed with cold acetone
  6. customto give
  7. customupon drying

Quellen und Nachweise

ORD-Eintrag
ord-b6175eeac55148129b4ba8d24ceb3f10
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04723002

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