3,4-Dichloroaniline → N-(3,4-dichlorophenyl)alanine Benzyl Ester

HRID 411418

Reaktionsgleichung

Reaktionsgleichung von HRID 411418
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[C:10]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:14])[C:11]([CH3:13])=O>>[CH2:16]([O:15][C:10](=[O:14])[C@H:11]([CH3:13])[NH:5][C:4]1[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

3

Edukt 2

HCID 72573,4-DichloroanilineHCID 11769098Benzyl 2-oxopropanoate

Produkt 1

HCID 15434839N-(3,4-dichlorophenyl)alanine Benzyl Ester

Versuchsvorschrift

Following General Procedure AA above and using 3,4-dichloroaniline (Aldrich) and benzyl pyruvate (prepared by following General Procedure AO above using benzyl alcohol in place of iso-butanol), the title compound was prepared as an oil. The reaction was moniterd by tlc on silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).

Aufarbeitung

  1. customon silica gel (Rf=0.4 in 25% EtOAc/hexanes) and purification

Quellen und Nachweise

ORD-Eintrag
ord-4247b2ad81ca43969d3e83ab82a46f48
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559141B2

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