1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 411554Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 411554
[N:1]1([CH2:7][CH2:8][OH:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[OH:9][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:10](=[O:12])[CH3:11])[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

Produkt 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazineAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g, 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.

Aufarbeitung

  1. additionadded dropwise
  2. additionDuring addition
  3. customrose from 22 to 60° C
  4. customThe reaction mixture was evaporated several times with toluene

Quellen und Nachweise

ORD-Eintrag
ord-719de8e84b1941b0afa086c4c952fcc5
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559162B2

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