Chlorotrimethylsilane → Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate

HRID 411887

Reaktionsgleichung

Reaktionsgleichung von HRID 411887
[CH3:1][C:2]1([CH3:10])[C:5](=O)[C:4]([CH3:8])([CH3:7])[C:3]1=[O:9].[CH3:11][O-:12].[Na+].C[Si:15](Cl)(C)C.[O:19]1[CH2:23]CCC1>>[CH3:10][C:2]([CH3:1])([C:3]([O:9][SiH3:15])=[C:4]([CH3:7])[CH3:8])[CH2:5][C:11]([O:19][CH3:23])=[O:12]

Komponenten

5

Edukt 4

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 136172,2,4,4-Tetramethyl-1,3-cyclobutanedioneHCID 10942334Sodium Methoxide

Produkt 1

HCID 123759875Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate

Versuchsvorschrift

84 g (0.6 mol) of 2,2,4,4-tetramethylcyclobutane-1,3-dione and 32.4 g (0.6 mol) of sodium methylate were mixed together in 320 ml of tetrahydrofuran. 65.1 g (0.6 mol) of trimethylsilyl chloride were added dropwise and the mixture was stirred. The reaction mixture was then concentrated and the residue was taken up with diethyl ether. The solid was filtered off with suction and the mother liquor was concentrated. Yield: 135 g (89%).

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated
  2. filtrationThe solid was filtered off with suction
  3. concentrationthe mother liquor was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-018233e2db2a44b78cd771c96c80a5be
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06559343B1

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