Sodium Iodide → N-[3-(iodoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

HRID 4119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 4119
Br[CH2:2][C:3]([N:5]1[CH2:9][CH2:8][N:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:6]1=[O:18])=[O:4].[I-:19].[Na+]>CC(C)=O>[I:19][CH2:2][C:3]([N:5]1[CH2:9][CH2:8][N:7]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:6]1=[O:18])=[O:4]

Komponenten

4

Edukt 2

HCID 5238Sodium IodideHCID 57105682N-[3-(Bromoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

Produkt 1

HCID 57241819N-[3-(iodoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

N-[3-(Bromoacetyl)-2-oxo-1-imidazolidinyl]carbamic acid, 1,1-dimethylethyl ester (20.9 g, 65 mmol) was dissolved in acetone (250 ml) containing sodium iodide (10.5 g, 70 mmol). The solution was stirred at reflux for three hours and filtered hot through Celite. The solution was evaporated in vacuo to give the title compound as a light yellow solid, 23.9 g.

Aufarbeitung

  1. temperatureat reflux for three hours
  2. filtrationfiltered hot through Celite
  3. customThe solution was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-71dd9c746bed41b09c643f7528bb9407
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04723002

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