Gamma-Aminobutyric Acid → Alendronic Acid

HRID 412674

Reaktionsgleichung

Reaktionsgleichung von HRID 412674
[P:1]([OH:4])([OH:3])[OH:2].[NH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O.P(Cl)(Cl)Cl>>[CH2:7]([CH2:6][NH2:5])[CH2:8][C:9]([P:1]([OH:4])([OH:3])=[O:2])([P:1]([OH:4])([OH:3])=[O:2])[OH:11]

Komponenten

4

Edukt 3

HCID 119Gamma-Aminobutyric AcidHCID 24387Phosphorus trichlorideHCID 107909Phosphorous acid

Produkt 1

HCID 2088Alendronic Acid

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

The mixture of 5 eq. phosphorous acid, 4-aminobutyric acid and morpholine. HCl is melted together until uniform solution is formed. The reaction mixture is cooled to about 70° C. and 2 eq. of PCl3 are carefully added. The mixture is heated for about 5.5 hours before the reaction mixture is hydrolyzed in aqueous acid at about 80° C. and alendronate is isolated from an ethanolic solution.

Aufarbeitung

  1. customis formed
  2. temperatureThe mixture is heated for about 5.5 hours before the reaction mixture
  3. customis hydrolyzed in aqueous acid at about 80° C.

Quellen und Nachweise

ORD-Eintrag
ord-b3a0f7fd2bd7403f9357ce99aee0cb71
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06562974B2

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