Ammonia → 2,3,5-Trifluoro-6-nitroaniline

HRID 412726

Reaktionsgleichung

Reaktionsgleichung von HRID 412726
F[C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[C:4]([F:10])[C:3]=1[N+:11]([O-:13])=[O:12].[NH3:14].O1CCOCC1>O>[F:8][C:7]1[C:6]([F:9])=[CH:5][C:4]([F:10])=[C:3]([N+:11]([O-:13])=[O:12])[C:2]=1[NH2:14]

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 312751,4-DioxaneHCID 675661,2,3,5-Tetrafluoro-4-nitrobenzene

Produkt 1

HCID 2230852,3,5-Trifluoro-6-nitroanilineAusbeute 51 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution comprising 2,3,4,6-tetrafluoronitrobenzene (0.6 g, 3.1 mmol) and ammonia in dioxane (Aldrich, 0.5M, 7.5 mmol) was stirred at room temperature for 3 hours to give a fine white precipitate. The mixture was diluted with an equal volume of water to dissolve the white precipitate and give yellow crystals. The crystals were isolated were collected and dried to provide 2,3,5-trifluoro-6-nitroaniline (307 mg, 51%) as yellow needles; m.p. 66° C.; 1H NMR (CDCl3) δ 6.4 (1H, m), δ 6.0 (2H, s).

Aufarbeitung

  1. customto give a fine white precipitate
  2. dissolutionto dissolve the white precipitate
  3. customgive yellow crystals
  4. customThe crystals were isolated
  5. customwere collected
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-63bd390fc9ae4e0e94c0a4d53118d5a4
Quelldatensatz
uspto-grants-2003_05
Patentnummer
US06562854B2

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