Mandelic Acid → 10-methoxy-5H-dibenz(b,f)azepine-5-carboxamide

HRID 41346

Reaktionsgleichung

Reaktionsgleichung von HRID 41346
[CH3:1][O:2][C:3]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[O-:18][C:19]#[N:20].[Na+].C(O)(=O)C(C1C=CC=CC=1)O.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]([C:19]([NH2:20])=[O:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1

Komponenten

6

Edukt 4

HCID 1292Mandelic AcidHCID 14798Sodium HydroxideHCID 7842410-MethoxyiminostilbeneHCID 517096Sodium Cyanate

Produkt 1

HCID 12003110-methoxy-5H-dibenz(b,f)azepine-5-carboxamideAusbeute 83,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A suspension of 10 g of 10-methoxyiminostilbene in 200 ml toluene was treated with 20 g of sodium cyanate and 39 g of mandelic acid and was heated to reflux for about 10 hrs. The reaction mixture was cooled to room temperature and charged with sodium hydroxide solution and maintained for 19 hrs. The resulting suspension was filtered, washed with water and dried to give 10 g of 10-methoxy carbamazepine.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for about 10 hrs
  3. temperaturemaintained for 19 hrs
  4. filtrationThe resulting suspension was filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-d481f292f5d5474a8f07a889c5a31c7f
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530647B2

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