Water → 3-(4-Trifluoromethylphenylthio)propanal

HRID 414030

Reaktionsgleichung

Reaktionsgleichung von HRID 414030
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[CH:12]([CH:14]=[CH2:15])=[O:13].O>C1COCC1.C(N(CC)CC)C>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([S:9][CH2:15][CH2:14][CH:12]=[O:13])=[CH:7][CH:8]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 7847AcroleinHCID 1366534-(Trifluoromethyl)thiophenol

Produkt 1

HCID 143479823-(4-Trifluoromethylphenylthio)propanalAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8471TriethylamineKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Ten grams of 4-trifluoromethylthiophenol was dissolved in 15 ml of THF, and after adding 4.0 g of 95% acrolein under ice-cooling, 0.1 g of triethylamine was added while thoroughly stirring the reaction solution. After stirring for 1.5 hours under ice-cooling, the reaction solution was poured into water and extracted with ether. The ether layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 13.1 g of 3-(4-trifluoromethylphenylthio)propionaldehyde.

Aufarbeitung

  1. temperaturecooling
  2. stirringAfter stirring for 1.5 hours under ice-
  3. temperaturecooling
  4. extractionextracted with ether
  5. washThe ether layer was washed with water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8fffb9f5120448a293a9012ddff4bfe1
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04789396

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