Hydrogen Bromide → HCID 19850133, Verbindung

HRID 414390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 414390
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:5]=[CH:4][C:3]=1[OH:26].[BrH:27]>[PH2](O)=O>[BrH:27].[BrH:27].[F:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][NH:17][CH2:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:5]=[CH:4][C:3]=1[OH:26]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 19850134HCID 19850134, Verbindung

Produkt 1

HCID 19850133HCID 19850133, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 4124402Phosphinic AcidKatalysator

Versuchsvorschrift

The product from step (b) (1.8 g) in 48% hydrobromic acid (18 ml) containing hypophosphorous acid (10 drops) was boiled at reflux under nitrogen for 5.5 hr. The solid which separated on cooling the solution was collected and recrystallised from water giving the dihydrobromide salt of the title compound as colourless needles (1.3 g) mp 240.5°-242.5°.

Aufarbeitung

  1. temperatureat reflux under nitrogen for 5.5 hr
  2. customThe solid which separated
  3. temperatureon cooling the solution
  4. customwas collected
  5. customrecrystallised from water giving the dihydrobromide salt of the title compound as colourless needles (1.3 g) mp 240.5°-242.5°

Quellen und Nachweise

ORD-Eintrag
ord-867d94ca17a6452db859bbe8c9a780c0
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04791216

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