Phenyl isocyanate → Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

HRID 414420Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 414420
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH:5]2[C:12]([O:14][CH3:15])=[O:13].[C:16]1([N:22]=[C:23]=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C1(C)C=CC=CC=1>[C:16]1([NH:22][C:23]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=3)[CH:5]([C:12]([O:14][CH3:15])=[O:13])[C:6]2=[O:11])=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Komponenten

4

Edukt 2

HCID 7672Phenyl isocyanateHCID 21282067methyl 5-chloro-2-oxo-2,3-dihydro-1H-indole-3-carboxylate

Produkt 1

HCID 14097011Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux overnight
  3. temperatureThe reaction mixture was cooled
  4. customto give
  5. filtrationafter filtration
  6. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-c913b7537d774f86bd92b58e2f9df6c3
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04791129

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