Acetic Acid → 4-Methyl-6-acetamido-7-hydroxy-1-indanone

HRID 414678

Reaktionsgleichung

Reaktionsgleichung von HRID 414678
[CH3:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15].[C:16](O)(=[O:18])[CH3:17]>[C].[Pd]>[CH3:1][C:2]1[CH:10]=[C:9]([NH:11][C:16](=[O:18])[CH3:17])[C:8]([OH:14])=[C:7]2[C:3]=1[CH2:4][CH2:5][C:6]2=[O:15]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 136041424-Methyl-6-nitro-7-hydroxy-1-indanone

Produkt 1

HCID 136041464-Methyl-6-acetamido-7-hydroxy-1-indanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 178418390HCID 178418390, VerbindungKatalysator

Versuchsvorschrift

Into a solution of 11.5 g of 4-methyl-6-nitro-7-hydroxy-1-indanone in 500 ml of acetic acid was added 1.5 g of 5% palladium carbon, then the mixture was subjected to a catalytic hydrogenation under an atmospheric pressure at a room temperature. The catalyst was removed by filtration and the solvent was removed by evaporation. The residue obtained was washed with ether and was recrystallized from methanol to obtain 6.34 g of 4-methyl-6-acetamido-7-hydroxy-1-indanone.

Aufarbeitung

  1. customwas subjected to a catalytic hydrogenation under an atmospheric pressure at a room temperature
  2. customThe catalyst was removed by filtration
  3. customthe solvent was removed by evaporation
  4. customThe residue obtained
  5. washwas washed with ether
  6. customwas recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-acbcc05080a54311b75436cdf25ec350
Quelldatensatz
uspto-grants-1988_12
Patentnummer
US04792628

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