MAGNESIUM SILICATE (synthetic) → Betulone Aldehyde

HRID 414903Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 414903
[O-][Si]([O-])=O.[Mg+2].C([O-])(=O)C.[Na+].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH3:22][C:23]([C@H:25]1[C@@H:29]2[C@@H:30]3[C@@:43]([CH3:46])([CH2:44][CH2:45][C@@:28]2([CH2:52][OH:53])[CH2:27][CH2:26]1)[C@@:42]1([CH3:47])[C@@H:33]([C@:34]2([CH3:51])[C@@H:39]([CH2:40][CH2:41]1)[C:38]([CH3:49])([CH3:48])[C@@H:37]([OH:50])[CH2:36][CH2:35]2)[CH2:32][CH2:31]3)=[CH2:24]>C(Cl)Cl>[CH3:24][C:23]([C@H:25]1[C@@H:29]2[C@H:30]3[C@@:43]([CH3:46])([CH2:44][CH2:45][C@@:28]2([CH:52]=[O:53])[CH2:27][CH2:26]1)[C@:42]1([CH3:47])[CH2:41][CH2:40][C@H:39]2[C:38]([CH3:49])([CH3:48])[C:37](=[O:50])[CH:36]=[CH:35][C@:34]2([CH3:51])[C@H:33]1[CH2:32][CH2:31]3)=[CH2:22]

Komponenten

6

Edukt 4

HCID 61680MAGNESIUM SILICATE (synthetic)HCID 72326BetulinHCID 517045Sodium AcetateHCID 178418287HCID 178418287, Verbindung

Produkt 1

HCID 44559212Betulone AldehydeAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a suspension of freshly activated powdered 4A molecular sieves (1.2 g), celite (1.2 g), florisil (1.2 g), sodium acetate (500 mg) and pyridinium chlorochromate (1.2 g) in CH2Cl2 (25 mL) add betulin (500 mg). The mixture is to be stirred for 2 hrs, and then filtered through a short column of silica gel. The filtrate is evaporated in vacuo. The residue is then subjected to column chromatography to afford betulone aldehyde (370 mg) as white solid.

Aufarbeitung

  1. additionTo a suspension
  2. filtrationfiltered through a short column of silica gel
  3. customThe filtrate is evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1845d7038c7d4ac7a5d33fed45637898
Quelldatensatz
uspto-grants-2012_01
Patentnummer
US08088757B2

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