Hydrochloric Acid → HCID 68817634, Verbindung

HRID 41498

Reaktionsgleichung

Reaktionsgleichung von HRID 41498
CS(C)=O.[ClH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]>CC(O)C>[ClH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 679Dimethyl Sulfoxide2×HCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

Produkt 1

HCID 68817634HCID 68817634, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Dimethyl sulfoxide (1 mL) and hydrochloric acid (22 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (99.37 mg). Dimethyl sulfoxide (2 mL) was added to and dissolved in the mixture while heating the mixture, 2-propanol (3 mL) was added to the mixture, and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (88.65 mg).

Aufarbeitung

  1. dissolutiondissolved in the mixture
  2. additionwas added to the mixture
  3. filtrationThe solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-d69699ced6d04373b7ba39101758b8fe
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530654B2

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