Hydrogen Bromide → HCID 68820841, Verbindung

HRID 41499

Reaktionsgleichung

Reaktionsgleichung von HRID 41499
CS(C)=O.[BrH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]>CC(O)C>[BrH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 679Dimethyl SulfoxideHCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

Produkt 1

HCID 68820841HCID 68820841, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

Dimethyl sulfoxide (1 mL) and hydrobromic acid (40 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (100.90 mg). 2-Propanol (5 mL) was added to the mixture while heating the mixture, and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (108.92 mg).

Aufarbeitung

  1. temperaturewhile heating the mixture
  2. filtrationThe solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c3aa049b7aa9465693f6054ed6d6261f
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08530654B2

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